Uranium-235 is the IC2 fissile isotope crafted from nine tiny piles and used to build Nuclear Reactor fuel rods.
Guide
Locate Uranium Ore in IC2 worldgen and process it through the Macerator, Ore Washing Plant, and Thermal Centrifuge chain to separate isotopes.
Run the enrichment chain repeatedly until you have at least 9 Tiny Piles of Uranium-235 in your inventory.
Place 9 Tiny Piles of Uranium-235 in a 3x3 crafting grid to produce 1 full Uranium-235 isotope.
Combine Uranium-235 with Uranium-238 and an iron or tin casing on the workbench to build a charged Fuel Rod.
Insert the Fuel Rod into the IC2 Nuclear Reactor with adjacent Coolant Cells and Heat Vents, then power the reactor to generate EU.
Uranium-235 produces large amounts of heat; without sufficient cooling components the reactor can melt down and destroy nearby blocks.
Place 9 Tiny Piles of Uranium-235 in a 3x3 crafting grid to produce 1 full Uranium-235 isotope.
Uranium-235 is the fissile fuel component for IC2 Fuel Rods, which power the Nuclear Reactor at very high EU/t output.
No, Uranium-235 is never an ore; it is extracted from Uranium Ore via the Thermal Centrifuge or recovered from depleted fuel rods.
Uranium-235 sustains the fission chain reaction inside the reactor, while Uranium-238 is the non-fissile filler used to bulk out fuel rods.
Uranium-235 is part of Industrial Craft 2 Classic and Experimental, mainly for Minecraft 1.7.10 and 1.12.2.